Experimental Studies on Atebrin

Studies on the Action of Atebrin in Plasmodium Infection of Monkeys

On the Mode of Action of Atebrin on Plasmodium Knowlesi—A Preliminary Note

The question as to whether atebrin acts directly on the parasites or exerts its action in an indirect manner, as suggested bv several workers in the case of quinine, has not been definitely settled. Kirschbaum (1923) observed that after mixing in vitro quinine solution of a strength of 1 : 5.000 with an equal quantity of blood in which Plasmodium vivax were present and keeping the mixture for 5...

A Comparative Study of the Action of Atebrin and Atebrin-Plasmochin Combination on Indian Strains of Malaria

In the attempt to find some drug that will effect a permanent cure in malaria the medical profession in this country has started using combinations of different anti-malarial remedies. Tablets containing these combinations in various proportions have been put on the market by well-known firms and are being extensively used. For instance, plasmochin has been combined with quinine and atebrin in ...

Crinodora (Palusan) in Indian Strains of Malaria

After the synthesis and successful trials of atebrin in the treatment of malaria, a number of acridine derivatives closely resembling it in chemical composition and properties were prepared. In France, ' quinacrine ' was synthesized and in the U.S.S.R. 1 acriquineSoon after, S. A. Farmaceutici Italia Milano synthesized a similar compound which they called ' Palusan' and later ' Crinodora ', the...

Effect of salts and electron transport on the conformation of isolated chloroplasts. I. Light-scattering and volume changes.

Whole chloroplasts isolated from the leaves of spinach (Spinacia oleracea L.) exhibit 2 types of conformational change during electron transport. Amine-uncoupled chloroplasts swell and atebrin-uncoupled chloroplasts shrink. Chloroplasts uncoupled by carbonylcyanide phenylhydrazones and by treatment with ethylenediamine tetraacetic acid do not change their volumes or light-scattering properties ...